Hypno Dude centers around Kirk Taylor, a 17-year-old American attending the International Diplomatic Corps High School in Kathmandu, Nepal. Kirk lives an unusual life as the son of a U.S. diplomat mother and a late CIA agent father, frequently relocating and navigating diverse cultures. At school, Kirk finds himself enrolled in an unusual, secretive class on hypnotism taught by an aged Asian hypnotist named Herkomus. Although initially disinterested and skeptical of his abilities, Kirk discovers he possesses a unique talent for hypnosis.

Unbeknownst to him, his skills position him as a critical figure against an emerging global threat. Across the globe, a sinister billionaire named Fernando Manuro, a powerful hypnotist himself, orchestrates plans for world domination through manipulation and strategic warfare. Fernando secretly controls international figures, creating chaos to consolidate power.